C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/82 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61K 31/4439 (2006.01) A61K 31/496 (2006.01) A61K 31/519 (2006.01) C07D 263/58 (2006.01) C07D 417/06 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2722586
The invention relates to substituted benzothiazoles, benzoxazoles - and their counterparts having pyridine and pyrimidine rings replacing the benzene ring - that are are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula (I) in which A and B are carbocycles or heterocycles. A particular embodiment is formula (AB).
L'invention concerne des benzothiazoles substitués, des benzoxazoles - et leurs équivalents avec des anneaux de pyridine et de pyrimidine remplaçant l'anneau benzénique - qui sont des inhibiteurs de la PDE4 utiles pour le traitement d'un accident vasculaire cérébral, d'un infarctus du myocarde et de troubles d'inflammation cardiovasculaire, ainsi que des compositions pharmaceutiques qui comprennent ces composés et des procédés pour le traitement d'un accident vasculaire cérébral, d'un infarctus du myocarde et de troubles d'inflammation cardiovasculaire chez un mammifère. Les composés ont la formule générale (I) dans laquelle A et B sont des carbocycles ou des hétérocycles. Un mode de réalisation particulier de l'invention correspond à la forme (AB).
Burgin Alex
Gurney Mark
Kiselyov Alexander
Rao Munagala
Sandanayaka Vincent
Cassan Maclean
Decode Genetics Ehf
LandOfFree
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