Substituted benzodiazepinones, benzoxazepinones and...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 267/14 (2006.01) A61K 31/5513 (2006.01) A61K 31/553 (2006.01) A61K 31/554 (2006.01) C07D 243/14 (2006.01) C07D 281/10 (2006.01)

Patent

CA 2677331

The present invention is directed to substituted benzodiazepinones, benzoxazepinones and benzothiazepinones compounds that are sodium channel blockers useful for the treatment of chronic and neuropathic pain. The compounds of the present invention are also useful for the treatment of other conditions, including disorders of the CNS such as anxiety, depression, epilepsy, manic depression and bipolar disorder. This invention also provides pharmaceutical compositions comprising a compound of the present invention, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. This invention further comprises methods for the treatment of acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain and disorders of the CNS including, but not limited to, epilepsy, manic depression, depression, anxiety and bipolar disorder comprising administering the compounds and pharmaceutical compositions of the present invention.

L'invention concerne des composés de benzodiazépinones, benzoxazépinones et benzothiazépinones substitués qui sont des bloqueurs de canaux sodiques utiles pour le traitement d'une douleur chronique et neuropathique. Les composés de la présente invention sont également utiles pour le traitement d'autres états, y compris des troubles du CNS comme l'anxiété, la dépression, l'épilepsie, une dépression chronique et un trouble bipolaire. L'invention fournit également des compositions pharmaceutiques comprenant un composé de la présente invention, seul ou en combinaison avec un ou plusieurs composés thérapeutiquement actifs, et un support pharmaceutiquement acceptable. L'invention concerne en outre des procédés pour le traitement de la douleur aigue, de la douleur chronique, de la douleur viscérale, de la douleur inflammatoire, de la douleur neuropathique et de trouble du CNS y compris, mais sans s'y limiter, l'épilepsie, une dépression chronique, une dépression, une anxiété et un trouble bipolaire, comprenant l'administration des composés et compositions pharmaceutiques de la présente invention.

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