C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/228, 260/272
C07D 451/00 (2006.01) A61K 31/44 (2006.01) C07D 453/02 (2006.01)
Patent
CA 1293256
Abstract: The invention provides a bicyclic heterocyclic carboxylic acid alkylene bridged piperidyl ester or amide in which the alkylene bridge contains a minimum of 3 carbon atoms and is attached to two of the piperidyl ring carbon atoms with the proviso that the bicyclic heterocycle does not contain two oxygen atoms, as well as acid addition salts and quaternary ammonium salts thereof. Production of the compounds includes the step of condensing an appro- priate bicyclic heterocyclic carboxylic acid or a reactive acid derivative thereof, or a precursor of the acid or derivative, with an appropriate alkylene bridged piperidyl amine or piperindinol, or a precursor thereof, and as necessary converting the resultant piperidyl ester or amide, or acid addition salt or quaternary ammonium salt thereof into the required piperidyl ester or amide or acid addition salt or quaternary ammonium salt thereof and recovering the resultant piperidyl ester or amide as such or as an acid addition salt or as a quaternary ammonium salt thereof, They are useful intermediates in the production of products having seratonin M antagonist activity.
580287
Donatsch Peter
Engel Gunter
Hugi Bruno
Richardson Brian Peter
Stadler Paul Albert
Fetherstonhaugh & Co.
Novartis Ag
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