Substituted benzoic acid derivatives having nf-kb inhibiting...

Details Substituted benzoic acid derivatives having nf-kb inhibiting... Substituted benzoic acid derivatives having nf-kb inhibiting...

C - Chemistry, Metallurgy

07

C

C07C 65/24 (2006.01) A61K 31/167 (2006.01) A61K 31/192 (2006.01) A61K 31/235 (2006.01) A61K 31/4409 (2006.01) A61K 31/4418 (2006.01) A61K 31/4453 (2006.01) A61K 31/4545 (2006.01) A61K 31/5375 (2006.01) A61K 31/5377 (2006.01) A61P 1/00 (2006.01) A61P 1/16 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) A61P 33/06 (2006.01) A61P 35/02 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01) C07C 66/00 (2006.01) C07C 69/94 (2006.0

Patent

CA 2429005

Substituted benzoic acid derivatives represented by the general formula (|) and exhibiting NF-.kappa.B inhibiting activity: (|) (||) (|||) wherein R3, R4, and R5 are each independently hydrogen, C1-6 alkyl, or C1-6 alkoxy; R9 and R10 are each independently hydrogen, C1-6 alkyl, or C2-11 acyl; R2 is an optionally substituted aromatic hydrocarbon group or an optionally substituted heterocyclic group; and X is carboxyl which may be converted into an ester or an amide.

L'invention concerne des dérivés d'acide benzoïque substitués représentés par la formule (1) et possédant une activité d'inhibition de NF-KB. Dans cette formule, R3, R4 et R5 représentent chacun indépendamment hydrogène, C1-6 alkyle ou C1-6 alcoxy; R9 et R10 représentent chacun indépendamment hydrogène, C1-6alkyle ou C2-11acyle; R2 représente un groupe hydrocarbure aromatique ou un groupe hétérocyclique éventuellement substitué; et X représente carboxyle pouvant être converti en un ester ou un amide.

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