Substituted benzopyran derivatives against arrhythmia

Details Substituted benzopyran derivatives against arrhythmia Substituted benzopyran derivatives against arrhythmia

C - Chemistry, Metallurgy

07

D

C07D 311/68 (2006.01) A61K 31/353 (2006.01) A61P 9/06 (2006.01)

Patent

CA 2450541

This invention relates to benzopyran derivatives of the formula (1) or the formula (2) wherein R1 and R2 represent independently of each other hydrogen atom or C1-6alkyl group, R3 represents hydroxyl group or C1-6 alkylcarbonyloxy group, R4 represents hydrogen atom or C1-6 alkyl group, R5 represents C1-6 alkyl group substituted with C6-14 aryl group or heteroaryl group, R6 represents C1-6 alkyl group, C1-6 alkoxy group, halogen atom, nitro group, C(O)NH2, C(O)NHR8 or C(O)NR8R9, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent.

L'invention concerne des dérivés de benzopyrane de la formule (1) ou de la formule (2) suivantes, dans lesquelles R?1¿ et R?2¿ représentent indépendamment l'un de l'autre un atome d'hydrogène ou un groupe C¿1-6 ?alkyle, R?3¿ représente un groupe hydroxyle ou un groupe C¿1-6 ?alkylcarbonyloxy, R?4¿ représente un atome d'hydrogène ou C¿1-6 ?alkyle, R?5¿ représente un groupe C¿1-6 ?alkyle substitué par un groupe C¿6-14 ?aryl ou un groupe hétéroaryle. R?6¿ représente un groupe C¿1-6 ?alkyle, un groupe C¿1-6 ?alcoxy, un atome halogène, un groupe nitro, C(O)NH¿2?, C(O)NHR?8¿ ou C(O)NR?8¿R?9¿, ou un sel de ceux-ci pharmaceutiquement acceptables. Ces composés peuvent servir comme agent antiarythmique.

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