C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/34 (2006.01) A61K 31/426 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2382573
The invention provides novel substituted benzylthiazoli- dine-2,4-dione derivatives which increase the transactivation action of receptor as a ligand of human peroxisome proliferator-activated receptor (PPAR) and exhibit the blood glucose-decreasing action and lipid-decreasing action, and a process for preparing them. The invention relates to substituted benzylthiazolidine- 2,4-dione derivatives represented by the general formula (1) Image [wherein A denotes a phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents], their medicinally acceptable salts, their hydrates and a process for preparing them.
L'invention concerne des dérivés de benzylthiazolidine-2,4-dione substitués, capables, comme ligand du récepteur activé par les proliférateurs des peroxysomes (PPAR) humain, de renforcer l'activité transcriptionnelle du récepteur et de faire baisser les taux de glucose sanguin et de lipides; et un procédé de production de ces dérivés. L'invention concerne de nouveaux dérivés de benzamide substitués représentés par la formule générale (1), des sels et des hydrates pharmaceutiquement acceptables de ceux-ci. Dans la formule, A représente phényle éventuellement substitué, phénoxy éventuellement substitué ou benzyloxy éventuellement substitué.
Miyachi Hiroyuki
Murakami Koji
Nomura Masahiro
Tanase Takahiro
Tsunoda Masaki
Borden Ladner Gervais Llp
Kyorin Pharmaceutical Co. Ltd.
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