Substituted benzylthiazolidine-2,4-dione derivatives

Details Substituted benzylthiazolidine-2,4-dione derivatives Substituted benzylthiazolidine-2,4-dione derivatives

C - Chemistry, Metallurgy

07

D

C07D 277/34 (2006.01) A61K 31/426 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2382582

Substituted benzylthiazolidine-2,4-dione derivatives capable of, as a ligand of human peroxisome proliferator-activated receptor (PPAR), enhancing the transcriptional activity of the receptor and showing effects of lowering blood sugar level and lowering lipid level; and a process for producing the same. Substituted benzylthiazolidine-2,4-dione derivatives represented by general formula (1), pharmaceutically acceptable salts thereof and hydrates of the same, wherein R1 represents chloro, bromo, nitro, trifluoromethoxy, ethoxy, propoxy or isopropoxy; and R2 represents hydrogen or chloro.

L'invention concerne des dérivés de benzylthiazolidine-2,4-dione substitués, capables, comme ligand du récepteur activé par les proliférateurs des peroxysomes (PPAR) humain, de renforcer l'activité transcriptionnelle du récepteur et de faire baisser les taux de glucose sanguin et de lipides; et un procédé de production de ces dérivés. L'invention concerne des dérivés de benzylthiazolidine-2,4-dione substitués représentés par la formule générale (1), des sels et des hydrates pharmaceutiquement acceptables de ceux-ci. Dans la formule, R?1¿ représente chloro, bromo, nitro, trifluorométhoxy, éthoxy, propoxy ou isopropoxy; et R?2¿ représente hydrogène ou chloro.

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