Substituted .beta.-carbolines, process for the preparation...

Details Substituted .beta.-carbolines, process for the preparation... Substituted .beta.-carbolines, process for the preparation...

C - Chemistry, Metallurgy

07

D

167/231, 260/276

C07D 471/04 (2006.01) A61K 31/44 (2006.01)

Patent

CA 1263394

Abstract Novel substituted .beta.-carboline derivatives of Formula I Image wherein Image R3 is an oxadiazolyl residue of the formula wherein R5 stands for lower alkyl of up to 3 carbon atoms or an ester ?-OR6 with R6 being hydrogen or lower alkyl of up to 3 carbon atoms, R4 is hydrogen, lower alkyl of up to 3 carbon atoms, or CH2OR9 wherein R9 is lower alkyl of up to 3 carbon atoms, RA is phenyl or a hydrocarbon residue containing 2-10 carbon atoms which can be cyclic or acyclic, satur- ated or unsaturated, branched or unbranched, and which can optionally be substituted by oxo, formyl, OH, O-alkyl of up to 3 carbon atoms or phenyl, and wherein, in a cyclic hydrocarbon residue, a CH2- group can be replaced by oxygen, exhibit an effect on the central nervous system and thus are suitable as psychopharmaceuticals.

464082

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