C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 317/24 (2006.01) A61K 31/12 (2006.01) A61P 11/00 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01)
Patent
CA 2336300
The invention relates to the compounds of formula (I) wherein one of X1 and X2 is MeSO2 and the other one is hydrogen or halogen and X3 is hydrogen or halogen. These compounds have been found to be useful in the prevention and the treatment of respiratory diseases, especially asthma, ARDS (Acute Respiratory Distress Syndrome), COPD (chronic obstructive pulmonary diseases), allergic rhinitis and related inflammatory conditions. More specifically, the invention relates to the use of said compound in the prevention and the treatment of asthma in steroid-resistant patients. The invention also relates to pharmaceutical formulations used in the treatment of said diseases.
L'invention concerne des composés de formule (I) dans laquelle X¿1? ou X¿2? représente MeSO¿2?, l'un deux représentant hydrogène ou halogène, et X¿3? représente hydrogène ou halogène. On a découvert que ces composés sont utiles dans la prévention et le traitement des maladies respiratoires, notamment de l'asthme, du SDRA (syndrome de détresse respiratoire aiguë), des bronchopneumopathies chroniques obstructives, des rhinites allergiques et des troubles inflammatoires associés. L'invention concerne, en particulier, l'utilisation dudit composé dans la prévention et le traitement de l'asthme chez des patients présentant une résistance aux stéroïdes. L'invention concerne, en outre, des formulations pharmaceutiques utilisées dans le traitement de ces maladies.
Aho Paivi
Backstrom Reijo
Koponen Anita
Linden Inge-Britt
Lonnberg Kari
Orion Corporation
Robic
LandOfFree
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