Substituted biaryl quinolin-4-ylamine analogues

Details Substituted biaryl quinolin-4-ylamine analogues Substituted biaryl quinolin-4-ylamine analogues

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/4985 (2006.01) A61K 31/506 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2584081

Substituted biaryl quinolin-4-ylamine analogues of Formula I are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

L'invention concerne des analogues de biaryl quinoline-4-ylamine à substitution, de formule I. Ces composés sont des ligands pouvant être utilisés pour moduler une activité de récepteur spécifique in vivo ou in vitro, et ils sont particulièrement utiles pour le traitement d'affections associées à l'activation de récepteur pathologique chez l'être humain, les animaux de compagnie domestiqués et le bétail. On décrit aussi des compositions pharmaceutiques et des procédés relatifs à l'utilisation des composés en question pour le traitement des troubles considérés, et des procédés d'utilisation de tels ligands pour les études de localisation de récepteur.

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