C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01) C07D 413/10 (2006.01)
Patent
CA 2650999
The present invention is directed to certain patentable substituted benzoxazole derivatives that exhibit protein kinase (PK) inhibition activity or modulating ability. Pharmaceutical compositions comprising these compounds, and methods for preparing and using them, are also described. For example, these heterocyclic compounds are useful in treating disorders related to abnormal PK activity, including diseases and disorders involving aberrant cell proliferation, for example, AML, CML, gastrointestinal stromal cancers, thyroid cancer, other cancers and leukemias, as well as other diseases such as inflammation and atherosclerosis.
La présente invention concerne certains dérivés de benzoxazole substitués brevetables, présentant une activité d'inhibition ou un pouvoir de modulation de la protéine kinase (PK). Elle concerne également des compositions pharmaceutiques contenant ces composés, et des méthodes de préparation et d'utilisation des compositions. Par exemple, ces composés hétérocycliques sont utiles pour le traitement de troubles liés à une activité anormale de PK, y compris des maladies et des troubles impliquant une prolifération cellulaire aberrante, tels que la LAM, la CML, les tumeurs du stroma gastro-intestinal, le cancer de la thyroïde, et d'autres cancers et leucémies, ainsi que d'autres maladies telles que l'inflammation ou l'athérosclérose.
Carter Bruce
Miranda Martin
Muthalif Mubarack
Pfahl Magnus
Pfahl Michaela
Carter Bruce
Miranda Martin
Muthalif Mubarack
Pfahl Magnus
Pfahl Michaela
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