C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4188 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2742914
The present invention is concerned with novel substituted bicyclic imidazole derivatives of Formula (I) wherein R0, R1, R3, R4, X, A1, A2, A3, A4, Y1, Y2 and Y3 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said novel compound as an active ingredient as well as the use of said compounds as a medicament.
La présente invention porte sur de nouveaux dérivés bicycliques substitués d'imidazole de formule (I) dans laquelle R0, R1, R3, R4, X, A1, A2, A3, A4, Y1, Y2 et Y3 ont la signification définie dans les revendications. Les composés selon la présente invention sont utiles comme modulateurs de la gamma-sécrétase. L'invention porte en outre sur des procédés pour la préparation de tels nouveaux composés, sur des compositions pharmaceutiques comprenant ledit nouveau composé comme principe actif ainsi que sur l'utilisation desdits composés comme médicament.
Berthelot Didier Jean-Claude
Bischoff Francois Paul
Gijsen Henricus Jacobus Maria
Macdonald Gregor James
Trabanco-Suarez Andres Avelino
Gowling Lafleur Henderson Llp
Ortho-Mcneil-Janssen Pharmaceuticals Inc
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