C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) C07D 333/68 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2498106
The present invention addresses substituted thiophene derivatives, as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.
La présente invention concerne des dérivés de thiophène substitués, ainsi que des compositions contenant lesdits composés et des méthodes de traitement. Les composés selon la présente invention sont des antagonistes du glucagon. Lesdits composés bloquent l'action du glucagon au niveau de son récepteur et diminue ainsi les taux de glucose du plasma, ce qui permet le traitement du diabète.
Campbell Elizabeth Louise
Duffy Joseph
Konteatis Zenon
Liang Rui
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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