C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 59/68 (2006.01) A61K 31/192 (2006.01) A61K 31/196 (2006.01) A61P 25/28 (2006.01) C07C 229/42 (2006.01)
Patent
CA 2650006
The present invention relates to compounds having the general Formula (I) with the definitions of X, Y, R1, R2, R3, R4 R9, and R10, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of .gamma.-secretase activity, wherein A is O, NH, S; X is a bond or a group -CR5R6 .UPSILON. is a carboxy group -C(O)OH or a substituted or unsubstituted tetrazole group..
La présente invention concerne des composés répondant à la formule générale (I), dans laquelle X, Y, R1, R2, R3, R4, R9 et R10 sont tels que définis ci-après, et/ou leurs sels ou esters. L'invention concerne, en particulier, l'utilisation desdits composés dans le traitement de la maladie d'Alzheimer ainsi que dans la modulation de l'activité .gamma.-sécrétase. Dans la formule (I), A représente O, NH, S; X représente une liaison ou un groupe -CR5R6; et Y représente un groupe carboxylique -C(O)OH ou un groupe tétrazole substitué ou non substitué.
Boussard Cyrille
Burckhardt Svenja
Cansfield Andrew
Harrison Richard John
Hernadez-Perni Remedios
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cellzome Limited
Ortho-Mcneil Pharmaceutical Inc.
Ortho-Mcneil-Janssen Pharmaceuticals Inc.
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