C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 317/14 (2006.01) A61K 31/10 (2006.01) A61K 31/18 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 311/16 (2006.01) C07C 311/24 (2006.01) C07C 311/29 (2006.01) C07C 311/39 (2006.01) C07C 317/22 (2006.01) C07C 317/32 (2006.01) C07C 323/67 (2006.01) C07D 207/33 (2006.01) C07D 213/24 (2006.01) C07D 213/26 (2006.01) C07D 263/32 (2006.01) C07D 277/22 (2006.01) C07D 307/38 (2006.01) C07D 317/52 (2006.01) C07D 317/56 (2006.01) C07D 317/58 (2006.01) C07D 319/18 (2006.01) C07D 333/06 (2006.01)
Patent
CA 2206257
A class of substituted biphenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (III), wherein each of R11 through R13 is independently selected from hydrido, halo, lower alkoxy, lower haloalkyl, amino, lower alkylamino, lower dialkylamino, and lower haloalkoxy; or wherein R11 and R12 together form -O(CH2)nO-; wherein n is 1-2, inclusive; or a pharmaceutically-acceptable salt thereof.
Composés diphényle substitués pour le traitement des inflammations et des affections liées à des inflammations. Les composés d'un intérêt particulier sont définis par la formule (III) dans laquelle chaque R?11¿ à R?13¿ est choisi séparément parmi hydrido, halo, alcoxy inférieur, haloalkyle inférieur, amino, alkylamino inférieur, dialkylamino inférieur et haloalcoxy inférieur; ou bien R?11¿ et R?12¿ forment ensemble -O(CH¿2?)¿n?O-, où n est égal à 1 ou 2; ou alors un sel de ces composés acceptable sur le plan pharmaceutique.
Li Jinglin
Norton Monica B.
Reitz David B.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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