Substituted biphenylsulfonamide endothelin antagonists

Details Substituted biphenylsulfonamide endothelin antagonists Substituted biphenylsulfonamide endothelin antagonists

C - Chemistry, Metallurgy

07

D

C07D 261/16 (2006.01) A61K 31/42 (2006.01) C07D 261/20 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2187576

Compounds of the formula Image inhibit the activity of endothelin. The symbols are defined as follows: R1 is Image R2 and R3 are each independently (a) hydrogen; (b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z1, Z2 and Z3; (c) halo; (d) hydroxyl; (e) cyano; (f) nitro; (g) -C(O)H or -C(O)R6; (h) -C02H or -C02R6; (i) -SH, -S(O)nR6, -S(O)m-OH, -S(O)m-OR6, -O-S(O)m-R6, -O-S(O)mOH or -O-S(O)m-OR6; (j) -Z4-NR7R8; or (k) -Z4-N(R11)-Z5-NR9R10; and the remaining symbols are as defined in the specification.

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