Substituted bis aryl and heteroaryl compounds as selective...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 209/08 (2006.01) C07D 231/56 (2006.01) C07D 235/26 (2006.01) C07D 239/96 (2006.01) C07D 249/18 (2006.01) C07D 263/58 (2006.01) C07D 265/34 (2006.01) C07D 277/68 (2006.01) C07D 401/14 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2598429

The present invention relates to a series of substituted bis aryl and heteroaryl compounds of formula (I): Wherein X, Y, Z, A, B, D, Ar, R1 and R2 are as defined herein. The compounds of this invention are selective 5HT2A antagonists, and are therefore, useful in treating a variety of diseases including but not limited to a wide variety of sleep disorders as disclosed and claimed herein.

La présente invention concerne une série de composés bis aryle et hétéroaryle substitués, représentés par la formule générale (I). Dans cette formule, X, Y, Z, A, B, D, Ar, R1 et R2 désignent des éléments définis dans la partie descriptive de la présente demande. Les composés de la présente invention sont des antagonistes sélectifs des récepteurs 5HT2A et sont, par conséquent, utiles pour le traitement de diverses maladies, notamment, mais sans en exclure d'autres, un grand nombre de troubles du sommeil.

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