Substituted bisindolymaleimides for the inhibition of cell...

Details Substituted bisindolymaleimides for the inhibition of cell... Substituted bisindolymaleimides for the inhibition of cell...

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/404 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2322689

Substituted pyrroles of formula (I) wherein R1 is hydrogen and R2 is methyl or R1 is methyl and R2 is hydrogen or R1 is hydroxymethyl and R2 is methyl as well as pharmaceutically acceptable prodrugs or pharmaceutically acceptable salts thereof are antiproliferative agents useful in the treatment of cancer.

Des pyrroles substitués de la formule (I), dans laquelle R<1> représente hydrogène et R<2> représente méthyle ou R<1> représente méthyle et R<2> représente hydrogène ou R<1> représente hydroxyméthyle et R<2> représente méthyle, ainsi que leurs promédicaments ou leurs sels acceptables sur le plan pharmaceutique, constituent des agents antiprolifératifs utiles dans le traitement du cancer.

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