Substituted butyrophenone derivatives

Details Substituted butyrophenone derivatives Substituted butyrophenone derivatives

C - Chemistry, Metallurgy

07

D

C07D 211/52 (2006.01) A61K 31/451 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2606757

The present invention relates to a central nervous system-acting substituted butyrophenones. These compounds are useful in antipsychotic medications for psychosis, including schizophrenia, but especially for L-DOPA-induced psychosis, while having low or no risk of eliciting extrapyramidal side effects, hyperprolactinemia or tardive dyskinesia.

La présente invention concerne des butyrophénones substitués agissant sur le système nerveux central. Ces composés sont utilisés dans des médicaments antipsychotiques destinés à traiter la psychose, y compris, la schizophrénie, mais notamment, la psychose induite par L-DOPA, tandis qu'ils présentent peu ou pas de risque d'éliciter des effets secondaires extrapyramidaux, une hyperprolactinémie ou une dyskinésie tardive.

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