Substituted carbazoles as inhibitors of spla2

Details Substituted carbazoles as inhibitors of spla2 Substituted carbazoles as inhibitors of spla2

C - Chemistry, Metallurgy

07

D

C07D 209/88 (2006.01) A61K 31/403 (2006.01) A61P 29/00 (2006.01) C07D 401/04 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2441077

Carbazoles of formula (I) with R2 = hydroxyfunctional amide (hydroxamic or esters) are disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.

L'invention concerne des carbazoles représentés par la formule (I), dans laquelle R?2¿ représente un amide hydroxyfonctionnel (acides hydroxamiques ou esters), ainsi que l'utilisation de ces composés pour inhiber la libération induite par sPLA¿2? d'acide gras, en vue de traiter des états pathologiques tels que le choc septique.

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