Substituted carboxylic acid derivaties

Details Substituted carboxylic acid derivaties Substituted carboxylic acid derivaties

C - Chemistry, Metallurgy

07

C

C07C 59/40 (2006.01) A61K 31/19 (2006.01) A61K 31/33 (2006.01) C07C 45/00 (2006.01) C07C 45/46 (2006.01) C07C 45/56 (2006.01) C07C 45/71 (2006.01) C07C 47/55 (2006.01) C07C 49/825 (2006.01) C07C 49/84 (2006.01) C07C 59/68 (2006.01) C07C 59/90 (2006.01) C07C 65/40 (2006.01) C07C 69/00 (2006.01) C07C 69/007 (2006.01) C07C 69/734 (2006.01) C07C 69/738 (2006.01) C07C 205/37 (2006.01) C07C 205/56 (2006.01) C07C 219/14 (2006.01) C07C 229/36 (2006.01) C07C 229/42 (2006.01) C07C 233/54 (2006.01) C07C 233/69 (2006.0

Patent

CA 2068076

RAN 4027/3 ABSTRACT The compounds of the formula Image wherein A, B, Q, R1, R2, R2', X, Y, Z and n are as described in claim 1, when appropriate, in the form of enantiomers, racemates, diastereomeres or mixtures thereof or geometric isomers or mixtures thereof and, when a basic or acidic group is present, pharmaceutically acceptable salts thereof, inhibit enzyme carnitine acyltransferase 1 (CAT- 1) and are therefore useful in the prevention of injury to ischemic tissue, and can limit infarct size, improve cardiac function and prevent arrhythmias during and following a myocardial infarction. They can be prepared according to various methods which are known per se.

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