Substituted carboxylic acids

Details Substituted carboxylic acids Substituted carboxylic acids

C - Chemistry, Metallurgy

07

D

C07D 307/80 (2006.01) A61K 31/16 (2006.01) A61K 31/34 (2006.01) C07C 53/136 (2006.01) C07C 69/616 (2006.01) C07C 229/18 (2006.01) C07C 233/65 (2006.01) C07D 209/08 (2006.01) C07D 263/56 (2006.01) C07D 277/66 (2006.01) C07D 307/91 (2006.01) C07D 307/92 (2006.01) C07D 405/10 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2523714

The present invention relates to compounds and pharmaceutically acceptable salts of formula (I) : which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTB-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.

L'invention porte sur des composés et des sels pharmaceutiquement acceptables représentés par la formule (I) et utiles dans le traitement de troubles métaboliques liés à la résistance à l'insuline ou l'hyperglycémie. Ces composés contiennent des inhibiteurs de protéine tyrosine phosphatase (PTP-1B) qui sont utiles au traitement des diabètes et d'autres maladies à médiation de PTB-1B, telles le cancer, les maladies neurodégénérescentes et similaires. Ces composés sont aussi utiles dans des compositions pharmaceutiques et des procédés de traitement des conditions susmentionnées.

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