Substituted chroman derivatives having cytochrome p450rai...

Details Substituted chroman derivatives having cytochrome p450rai... Substituted chroman derivatives having cytochrome p450rai...

C - Chemistry, Metallurgy

07

D

C07D 311/58 (2006.01) A61K 31/353 (2006.01) A61P 17/00 (2006.01)

Patent

CA 2478913

Compounds of the formula (I), where the variables are defined in the specification have cytochrome P450RAI-I and P450RAI-2 inhibitory activity, and are suitable for treatment of mammals with conditions which are treatable with retinoids, or which are controlled by or responsive to the organism's native retinoic acid. Formulations containing the compounds of the invention can also be co~administered with retinoids and/or Vitamin A to enhance or prolong the effects of medications containing retinoids, Vitamin A, or of the organism's native retinoic acid.

L'invention concerne des composés de formule (I), dans laquelle les variables sont définies dans la description. Ces composés présentent une activité inhibitrice du cytochrome P450RAI-1 et du cytochrome P450RAI-2, et sont appropriés au traitement de mammifères présentant des états pathologiques pouvant être traités au moyen de rétinoïdes, ou pouvant être contrôlés par de l'acide rétinoïque provenant de l'organisme, ou réagissant audit acide. Des formulations contenant les composés de l'invention peuvent également être co-administrées avec des rétinoïdes et/ou de la vitamine A pour accroître ou prolonger les effets des médicaments contenant des rétinoïdes, de la vitamine A ou de l'acide rétinoïque provenant de l'organisme.

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