Substituted cinnamyl-2,3-dihydrobenzofuran and analogs...

Details Substituted cinnamyl-2,3-dihydrobenzofuran and analogs... Substituted cinnamyl-2,3-dihydrobenzofuran and analogs...

C - Chemistry, Metallurgy

07

C

260/300, 260/356

C07C 43/23 (2006.01) C07C 43/225 (2006.01) C07C 45/44 (2006.01) C07C 47/575 (2006.01) C07C 49/248 (2006.01) C07C 49/835 (2006.01) C07C 49/84 (2006.01) C07D 307/79 (2006.01) C07D 307/82 (2006.01) C07D 311/58 (2006.01)

Patent

CA 1258855

Abstract of the disclosure The present invetnion relates to novel substituted cinnamyl-2,3-dihydrobenzofuran and analogs having the following formula: Image Image (I) (II) or a pharmaceutically acceptable salt thereof, wherein R is (a) hydroxyloweralkyl; (b) lower alkanoyl; (c) CN; (d) halo; (e) mercaptoloweralkyl; (f) loweralkylthio; (g) lowerhaloalkyl; (h) -COOR2 (i) hydroxycarbonylloweralkyl; (j) loweralkoxycarbonylloweralkyl; or (k) haloloweralkanoyl; m is 1 to4; n is 2 or 3; A is (a) phenyl substituted with (R1)q wherein when there are more than one R1 (q > 1) R1 can be the same or different from each other and is: (1) hydrogen; (2) halo; (3) loweralkoxy; (4) lower alkylthio; (5) lower alkyl sulfinyl; (6) lower alkyl sulfonyl; (7) unsubstituted or substituted phenyl substituted with 1 or 2 radicals selected from a group consisting fo loweralkoxy; halo; lowerhaloalkyl; loweralkanoyl; hydroxyloweralkyl; and CN; (8) loweralkyl; (9) loweralkenyl; (10) lower alkanoyl; (11) haloloweralkyl; (12) -COOH; (13) aryl; (14) aryloxy; (15) cyano; (16) hydroxyloweralkyl; (17) halo loweralkyl; (18) heteroaryl as defined below; or (19) loweralkanoyloxy; q is 0 to 5; (b) unsubstituted or substituted heteroaryl, selected from a group consisting of: (1) thienyl; (2) benzothienyl; (3) furyl; (4) benzofuryl; (5) pyrryl; (6) indolyl; (7) thiazolyl; (8) benzothiazolyl; (9) thiadiazolyl; (10) benzothiadiazolyl; (11) quinolyl; (12) isoquinolyl; (13) pyridyl; (14) pyrazinyl; (15) tetrazolyl;or (16) triazolyl; the heteroaryl above being substituted with one or more of R1.

465057

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