Substituted cyanopyridines as protein kinase inhibitors

Details Substituted cyanopyridines as protein kinase inhibitors Substituted cyanopyridines as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/85 (2006.01) A61K 31/465 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2650666

The present teachings provide compounds of formula (I) and their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide methods of making the compounds of formula (I), and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula (I) to a mammal including a human.

La présente invention a pour objet des composés de formule I XR R2 XN et leurs sels, hydrates et esters de qualité pharmaceutique, R1, R2 et X étant tels que définis dans la présente invention. La présente invention a également pour objet des méthodes de fabrication des composés de formule I, ainsi que des méthodes de traitement de maladies auto-immunes et inflammatoires par administration d'une quantité thérapeutiquement active d'un ou de plusieurs composés de formule I à un mammifère, y compris à un humain.

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