C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 203/08 (2006.01) C07D 207/08 (2006.01) C07D 211/32 (2006.01) C07D 213/50 (2006.01) C07D 241/04 (2006.01) C07D 401/06 (2006.01) C07D 401/08 (2006.01) C07D 403/08 (2006.01) C07D 405/08 (2006.01) C07D 407/08 (2006.01) C07D 413/08 (2006.01)
Patent
CA 2541509
The present invention provides compounds of the formula I: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non- crystalline forms, amorphous forms thereof, solvates thereof, metabolites thereof, and pharmaceutically acceptable salts, wherein the ring A substituent groups are fully defined in the following disclosure. The compounds of formula I are inhibitors of metalloproteases such as matrix metalloproteases and sheddases, and are useful in treating diseases such as rheumatoid arthritis, psoriasis, neoplastic diseases, allergies and all those diseases wherein inhibition of MMPs is desirable.
La présente invention concerne des composés représentés par la formule (I), ses énantiomères, diastéréomères, certains de leurs mélanges racémiques, promédicaments, formes cristallines, formes non-cristallines, formes amorphes, solvates, métabolites, et sels pharmaceutiquement admis, les groupes substituants du noyau étant ceux définis dans la présente demande. Les composés représentés par la formule (I), qui sont des inhibiteurs de métalloprotéases tels que les métalloprotéases matrices et les sheddases, conviennent particulièrement au traitement d'affections telles que l'arthrite rhumatoïde, le psoriasis, les affections néoplasiques les allergies et celles des affections dans lesquelles l'inhibition des métalloprotéases matrices s'avère bénéfique.
Burns David
Jalluri Ravi Kumar
Li Yun-Long
Yao Wenqing
Zhou Jincong
Incyte Corporation
Smart & Biggar
LandOfFree
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