Substituted cyclobutylamine derivative

Details Substituted cyclobutylamine derivative Substituted cyclobutylamine derivative

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) C07D 498/06 (2006.01)

Patent

CA 2292580

Substituted cyclobutylamine derivatives with novel structures represented by general formula (I), wherein R1 to R4 and Q represent each a specific substituent and, in particular, Q represents a quinolone derivative of a specific structure. These derivatives are useful as antibacterial compounds which have excellent antibacterial actions over a wide scope of bacteria including gram-negative and gram-positive ones, exert potent antibacterial activities particularly on methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae and quinolone-resistant bacteria and are excellent in the in vivo dynamics and safety.

L'invention porte sur des dérivés substitués de la cyclobutylamine de structures nouvelles de formule générale (I) dans laquelle R?1¿ à R?4¿ et Q représentent chacun un substituant spécifique, et où en particulier Q représente un dérivé de la quinolone de structure spécifique. Ces dérivés peuvent servir de composés antibactériens ayant une excellente action bactéricide sur une large gamme de bactérie dont les gram-positives et les gram-négatives et agissant puissamment sur le Staphylococcus aureus résistant à la méthicilline, sur le Streptococcus pneumoniae résistant à la pénicilline, et sur les bactéries résistant à la quinoline, tout en étant excellents du point de vue de la dynamique in vivo et de la sécurité.

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