C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/10 (2006.01) A61K 31/4725 (2006.01) A61P 3/04 (2006.01) A61P 15/00 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07D 211/70 (2006.01) C07D 217/26 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2519372
The present invention relates to novel substituted cyclohexyl and piperidinyl derivatives as melanocortin-4. receptor (MC-4R) modulators. MC-4R agonists of the invention can be used for the treatment of disorders and diseases such as obesity, diabetes and sexual dysfunction, whereas the MC-4R antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, anxiety and depression. All diseases and disorders where the regulation of the MC-4R is involved can be treated with the compounds of the invention.
Cette invention a trait à de nouveaux dérivés à substitution cyclohexyle et pipéridinyle agissant comme modulateurs de la mélanocortine 4 (MC-4R). Il est possible d'utiliser des agonistes de MC-4R pour le traitement de troubles et d'états pathologiques tels que l'obésité, le diabète et les dysfonctions sexuelles. Les antagonistes de MC-4R se révèlent des plus utiles pour traiter des troubles et des états pathologiques tels que la cachexie due au cancer, la perte de la masse musculaire, l'anorexie, l'anxiété et la dépression. Les composés selon l'invention permettent de traiter tous les états pathologiques et les troubles dans lesquels la régulation de MC-4R est impliquée.
Soeberdt Michael
von Sprecher Andreas
Weyermann Philipp
Robic
Santhera Pharmaceuticals (schweiz) Gmbh
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