Substituted deoxyadenosine derivatives

Details Substituted deoxyadenosine derivatives Substituted deoxyadenosine derivatives

C - Chemistry, Metallurgy

07

H

260/229.5

C07H 19/16 (2006.01)

Patent

CA 1182817

SUBSTITUTED DEOXYADENOSINE DERIVATIVES ABSTRACT OF THE DISCLOSURE Novel compounds of the following general formula I are useful pharmacological agents: Formula I Image wherein: Ado represents 5'-deoxyadenosin-5'-yl; R1 represents methyl, ethyl or, preferably hydrogen; R2 represents C1-C8 alkylene; R4 represents C1-C8 alkylene; R5 represents hydrogen, C1-C6 alkyl or -R6 NHR7; R6 represents C1-C4 alkylene; and R7 represents hydrogen or C1-C6 alkyl; and pharmaceutically acceptable acid addition salts thereof. These compounds are useful for treating those disorders associated with elevated levels of spermidine and/or spermine or pathogenic protazoa.

372620

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