Substituted derivatives

Details Substituted derivatives Substituted derivatives

C - Chemistry, Metallurgy

07

K

C07K 5/078 (2006.01) A61K 31/69 (2006.01) A61K 38/05 (2006.01) C07F 5/02 (2006.01) C07F 9/547 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2133657

2133657 9321214 PCTABScor01 The present invention relates to certain novel substituted derivatives which are 1-pyrimidinylacetamide derivatives of formula (I), set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted derivatives, processes for preparing the substituted derivatives, pharmaceutical compositions containing such substituted derivatives and methods for their use.

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