Substituted diarylureas as stimulators for fas-mediated...

Details Substituted diarylureas as stimulators for fas-mediated... Substituted diarylureas as stimulators for fas-mediated...

C - Chemistry, Metallurgy

07

C

C07C 275/42 (2006.01) A61K 31/17 (2006.01) A61P 19/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07C 275/30 (2006.01) C07C 309/65 (2006.01) C07C 317/42 (2006.01)

Patent

CA 2434020

Substituted diarylureas, pharmaceutical compositions containing them, and their use for stimulating Fas-mediated apoptosis. The compounds, as single stereoisomers or mixtures of stereoisomers, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them, are useful in methods of treating autoimmune diseases, infectious diseases, and malignancies.

La présente invention concerne des diarylurées substituées, des compositions pharmaceutiques les contenant et leur utilisation comme stimulateurs de l'apoptose à médiation des Fas. Ces composés, sous forme de stéréoisomères seuls ou mélanges de stéréoisomères, certains de leurs sels pharmaceutiquement admis, ainsi que des compositions pharmaceutiques les contenant, conviennent pour des procédures concernant le traitement d'affections auto-immunes, infectieuses et malignes.

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