C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/438 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2561975
This invention concerns substituted diaza-spiro-[4.5]-decane derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, a combined NK1/NK2 antagonist ic activity, a combined NK1/NK3 antagonist ic activity and a combined NK1/NK2/NK3 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment and/or prophylaxis of schizophrenia, emesis, anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disturbances, pre-eclampsia, nociception, pain, in particular visceral and neuropathic pain, pancreatitis, neurogenic inflammation, asthma, chronic obstructive pulmonary disease (COPD) and micturition disorders such as urinary incontinence. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
L'invention concerne des dérivés de diaza-spiro-[4.5]-décane substitués, antagonistes vis-à-vis de la neurokinine, en particulier NK¿1?, NK¿1?/NK¿2? combinée, NK¿1?/NK¿3? combinée et NK¿1?/NK¿2?/NK¿3? combinée, leur élaboration, des compositions qui les renferment, et leur utilisation comme médicaments pour le traitement et/ou la prévention de la schizophrénie, du vomissement, de l'anxiété et de la dépression, du syndrome du colon irritable, des troubles du rythme circadien, de la prééclampsie, de la nociception, de la douleur, en particulier viscérale et neuropathique, de la pancréatite, de l'inflammation neurogène, de l'asthme, de la bronchopneumopathie chronique obstructive, et des troubles de la miction du type incontinence urinaire. Les composés décrits peuvent être représentés par la formule (I), et ces composés s'entendent aussi de leurs sels d'addition d'acide ou basique, y compris les formes stéréochimiquement isomères correspondantes, la forme N-oxyde correspondante, et les promédicaments correspondants, pharmaceutiquement acceptables, tous les substituants étant tels que définis dans la revendication 1.
Coupa Sophie
Janssens Frans Eduard
Poncelet Alain Philippe
Schoentjes Bruno
Simonnet Yvan Rene Ferdinand
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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