C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) C07D 221/00 (2006.01) C07D 471/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2349451
Novel diazaanthracenes of formula (I) and (II) and wherein the dotted line in the central ring indicates that either the central ring is aromatically unsaturated, and in this case either R3 or H is absent from the 10-position and either R4 or H is absent from the 5-position, or the central ring is saturated and R3 and H and R4 and H are present, and the corresponding 5,10- diones, N-oxides, N-halides, N-amine, salts, dimers, Diels-Alder adducts, carbene adducts and complexes with transition metal compounds display valuable antibacterial, anticancer and antifungal properties. The compounds of formulae (I) and (II) in which R1 and R2 are both methyl groups can be obtained by subjecting 3,5-lutidine to the effect of a strong reducing agent, for example molten sodium.
L'invention concerne des diazaanthracènes des formules (I) et (II). La ligne en pointillé dans le noyau central indique que le noyau central est aromatiquement insaturé et, en l'occurrence, soit R?3¿, soit H est absent de la position 10, soit R?4¿, soit H est absent de la position 5. Autre possibilité, le noyau central est saturé et, par conséquent, R?3¿ et H, et R?4¿ et H sont présents. Les 5,10-diones, N-oxydes, N-halogénures, N-amine, sels, dimères, composés d'addition Diels-Alder, composés d'addition carbène et complexes correspondants avec composés métalliques de transition présentent de précieuses propriétés antibactériennes, anticancéreuses et antifongiques. Les composés des formules (I) et (II), dans lesquelles R?1¿ et R?2¿ sont tous deux des groupes méthyle, peuvent être obtenus en soumettant 3,5-lutidine à l'action d'un puissant agent de réduction, par exemple du sodium fondu.
Iyer Subramanian Sethuraman
Zaworotko Michael John
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