C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 255/40 (2006.01) A61K 31/075 (2006.01) A61K 31/12 (2006.01) A61K 31/16 (2006.01) A61K 31/21 (2006.01) A61K 31/277 (2006.01) A61K 31/336 (2006.01) A61K 31/357 (2006.01) A61P 35/00 (2006.01) C07C 43/188 (2006.01) C07C 43/192 (2006.01) C07C 49/697 (2006.01) C07C 69/157 (2006.01) C07C 69/757 (2006.01) C07C 69/76 (2006.01) C07C 235/34 (2006.01) C07C 235/82 (2006.01) C07C 251/44 (2006.01) C07C 255/36 (2006.01) C07D 303/48 (2006.01) C07D 317/20 (2006.01)
Patent
CA 2310750
The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.
Cette invention se rapporte à des composés d'indanone, d'indane et d'indole 3,3-diphényle substitués, ainsi qu'à des analogues de ces composés, qui constituent des inhibiteurs spécifiques, puissants et sûrs contre la prolifération cellulaire mammalienne. Ces composés peuvent servir à inhiber la prolifération cellulaire mammalienne in situ dans une approche thérapeutique de traitement ou de prévention des maladies se caractérisant par une prolifération cellulaire anormale, telle que le cancer.
Bellott Emile M. Jr.
Brugnara Carlo
Clifford John J.
Fluckiger Rudolf
Gao Ying-Duo
Children's Medical Center Corporation
Mbm Intellectual Property Law Llp
Nuchem Pharmaceuticals Inc.
Nuchem Pharmaceuticals Inc.
President And Fellows Of Harvard College
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