Substituted diphenylmethane derivatives as analgesic or...

Details Substituted diphenylmethane derivatives as analgesic or... Substituted diphenylmethane derivatives as analgesic or...

C - Chemistry, Metallurgy

07

D

C07D 233/60 (2006.01) A61K 31/415 (2006.01) A61K 31/495 (2006.01) C07D 249/08 (2006.01) C07D 295/155 (2006.01) C07D 333/20 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2043203

ABSTRACT A compound of formula I or a pharmaceutically acceptable salt thereof I Image I-bis Image where -R1 is hydrogen or methyl; -X- is -CO- or -CH2-; -Y- is >CH-A or its vinylogous group >C-CH-CH2-A, wherein -A is a -NR4R5 group, where each R4 and R5, equal or different between them, is C1-C4-alkyl or a phenyl-substituted C1-C4-alkyl; or -A is the N-radical of a 5- or 6-membered, uncharged (i.e. neither quaternary nor zwitterionic) monocyclic ring, either aromatic or non-aromatic, said ring containing one N atom, two N atoms, three N atoms or an N/O pair of atoms, all other atoms in the ring being carbon, and said ring being optionally mono- or di-substituted by groups selected from C1-C4 alkyl, benzyl, 2- furanylmethyl and 2-thienylmethyl; -R2 is hydrogen or a radical C1-C4-alkyl, C1-C4-alkoxy, di-(C1-C4-alkyl)amino, nitro or halogen, said radical being attached at the 2, 3 or 4 substitution positions of the phenyl ring; -R3 is hydrogen, phenyl, C1-C10-alkyl, a C3-C10-alkenyl or alkynyl group with the double or triple bond non- adjacent to the O-C bond, -(CH2CH2O) n-H with n = 1, 2 or 3, -(CHOH)m-H with m = 2, 3 or 4, or -when X is CO- the radical I-bis where Y is defined as above.

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