C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/4545 (2006.01) A61P 29/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2582225
Substituted dipiperidine compounds of Formula (I) or a salt, isomer, prodrug, metabolite or polymorph thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.
La présente invention concerne des composés à base de dipipéridine substituée, représentés par la formule générale (I), ou l'un de ses sels, isomères, promédicaments, métabolites ou polymorphes. Ces composés, qui sont des antagonistes anti-CCR2, conviennent pour la prévention, le traitement ou l'amélioration de syndromes, troubles ou affections à médiation par CCR2, dans le cas d'un sujet justifiant d'un tel traitement.
Demong Duane E.
Pan Meng
Pollack Scott R.
Wachter Michael P.
Xia Mingde
Janssen Pharmaceutica Nv
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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