Substituted estratrien derivatives as 17beta hsd inhibitors

Details Substituted estratrien derivatives as 17beta hsd inhibitors Substituted estratrien derivatives as 17beta hsd inhibitors

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/565 (2006.01) A61K 31/566 (2006.01) A61K 31/58 (2006.01) A61P 5/32 (2006.01) C07J 43/00 (2006.01) C07J 51/00 (2006.01)

Patent

CA 2671075

This invention relates to novel substituted estratrien derivatives of general formula (I) useful in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent disorder requiring the inhibition of a 17.beta.-hydroxysteroid dehydrogenase (17- HSD) type 1, type 2 and/or type 3 enzyme, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds.

Cette invention porte sur de nouveaux dérivés oestatriènes substitués de formule générale (I) utiles en thérapie, notamment pour une utilisation dans le traitement et/ou la prévention d'un trouble dépendant des hormones stéroïdiennes, nécessitant l'inhibition d'une enzyme 17.beta.-hydroxystéroïde déshydrogénase (17- HSD) de type 1, de type 2 et/ou de type 3, ainsi que sur leurs sels, sur des préparations pharmaceutiques contenant ces composés et sur des procédés pour la préparation de ces composés.

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