Substituted fused [1,2]imidazo[4,5-c] ring compounds and...

A - Human Necessities – 61 – K

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A61K 31/4745 (2006.01) C07D 471/04 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2597595

Fused [1,2]imidazo[4,5-c] ring compounds, e.g., fused [1,2]imidazo[4,5- c]quinolines and [1,2]imidazo[4,5-c]naphthyridines, with a substituent, e.g., a substituted alkoxy substituent, at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Cette invention concerne des composés cycliques [1,2]imidazo[4,5-c] fusionnés, tels que des [1,2]imidazo[4,5-c]quinoléines et des [1,2]imidazo[4,5-c]naphtyridines fusionnées, comprenant un substituant, tel qu'un substituant alcoxy substitué, en position 6, 7, 8, ou 9, des compositions pharmaceutiques contenant ces composés, des intermédiaires, des procédés de production et des procédés d'utilisation de ces composés comme immunomodulateurs pour induire la biosynthèse de cytokine chez des animaux ainsi que dans le traitement de maladies, telles que des maladies virales et néoplasiques.

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