Substituted fused pyrimidines as antagonists of gpr105 activity

Details Substituted fused pyrimidines as antagonists of gpr105 activity Substituted fused pyrimidines as antagonists of gpr105 activity

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2691010

Fused pyrimidine compounds of structural formula (I) are effective as antagonists of the biological activity of the GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and Metabolic Syndrome.

L'invention concerne des composés de pyrimidine fusionnée de formule structurale (I) qui sont efficaces comme antagonistes de l'activité biologique de la protéine GPR105. Ils sont utiles pour le traitement, le contrôle ou la prévention d'affections qui répondent à un antagonisme de ce récepteur, telles que le diabète, en particulier le diabète type 2, la résistance à l'insuline, l'hyperglycémie, les troubles lipidiques, l'obésité, l'athérosclérose et le syndrome métabolique.

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