Substituted guanidines and derivatives thereof as modulators...

Details Substituted guanidines and derivatives thereof as modulators... Substituted guanidines and derivatives thereof as modulators...

C - Chemistry, Metallurgy

07

C

C07C 279/16 (2006.01) A61K 31/155 (2006.01) A61K 31/17 (2006.01) A61K 31/275 (2006.01) A61K 31/277 (2006.01) A61K 31/33 (2006.01) A61K 31/34 (2006.01) A61K 31/37 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/4453 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/655 (2006.01) C07C 281/16 (2006.01) C07C 323/44 (2006.01) C07D 213/75 (2006.01) C07D 215/38 (2

Patent

CA 2099245

2099245 9214697 PCTABS00015 Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N, N', N", N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.

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