Substituted heteroaryls as inhibitors of protein tyrosine...

Details Substituted heteroaryls as inhibitors of protein tyrosine... Substituted heteroaryls as inhibitors of protein tyrosine...

C - Chemistry, Metallurgy

07

D

C07D 239/30 (2006.01) A61K 31/517 (2006.01) C07D 239/38 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 407/14 (2006.01) C07D 409/12 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2524221

Disclosed are compounds and pharmaceutically acceptable salts of formula (I), which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

L'invention concerne des composés et des sels pharmaceutiquement acceptables de formule (I) : (I), utilisés dans le traitement des troubles métaboliques liés à la résistance à l'insuline, à la résistance à la leptine ou à l'hyperglycémie. Les composés selon l'invention contiennent des inhibiteurs des protéine-tyrosine phosphatases, en particulier de la protéine-tyrosine phosphatase-1B (PTP-1B), utilisés dans le traitement du diabète et d'autres maladies à médiation PTP, telles que le cancer, les maladies neurodégénératives et analogues. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi que des méthodes de traitement des états susmentionnés au moyen desdits composés.

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