Substituted heterocycle fused gamma-carbolines

Details Substituted heterocycle fused gamma-carbolines Substituted heterocycle fused gamma-carbolines

C - Chemistry, Metallurgy

07

D

C07D 513/16 (2006.01) A61K 31/4353 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 221/18 (2006.01) C07D 223/00 (2006.01) C07D 223/32 (2006.01) C07D 281/00 (2006.01) C07D 335/00 (2006.01) C07D 337/00 (2006.01) C07D 471/00 (2006.01) C07D 471/06 (2006.01) C07D 471/16 (2006.01) C07D 473/00 (2006.01) C07D 487/16 (2006.01) C07D 491/06 (2006.01) C07D 495/06 (2006.01) C07D 513/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2373920

The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7, R8, R9, X, b, k, m, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.

Cette invention se rapporte à certains nouveaux composés représentés par la formule développée (I), ou à des sels de ces composés acceptables sur le plan pharmaceutique. Dans cette formule, R?1¿, R?5¿, R?6a¿, R?6b¿, R?7¿, R?8¿, R?9¿, X, b, k, m et n et les lignes en pointillés sont décrits dans la demande. Cette invention se rapporte également à des formulations pharmaceutiques comprenant ces nouveaux composés comme principes actifs et à l'utilisation de ces nouveaux composés et de leurs formulations dans le traitement de certaines affections. Ces composés sont des agonistes et des antagonistes de sérotonine et ils servent à empêcher ou à prévenir les troubles du système nerveux central tel, que obésité, anxiété, dépression, psychose, schizophrénie, troubles du sommeil, troubles sexuels, migraines, états associés aux douleurs céphaliques, phobies sociales et troubles gastro-intestinaux, tels que les dysfonctionnements de la motilité du tube digestif.

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