C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/404 (2006.01) A61K 31/4184 (2006.01) A61K 31/4355 (2006.01) A61K 31/4365 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) C07D 209/08 (2006.01) C07D 209/10 (2006.01) C07D 209/12 (2006.01) C07D 209/14 (2006.01) C07D 235/18 (2006.01) C07D 401/04 (2006.01) C07D 491/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2601983
This invention relates to novel compounds of Formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds possess CHK1 kinase inhibitory activity, PDK1 inhibitory activity and Pak kinase inhibitory activity and are accordingly useful in the treatment and/or prophylaxis of cancer.
La présente invention concerne des nouveaux composés de formule (I) et leurs compositions pharmaceutiques ainsi que leurs procédés d~utilisation. Ces nouveaux composés possèdent une activité inhibant la CHK1 kinase, une activité inhibant la PDK1 et une activité inhibant la Pak kinase. Ils sont dès lors utiles dans le traitement et/ou la prophylaxie du cancer.
Daly Kevin
Heron Nicola
Hird Alexander
Ioannidis Stephanos
Janetka James Walter
Astrazeneca Ab
Fetherstonhaugh & Co.
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