Substituted heterocyclic acyl-tripeptides useful as thrombin...

C - Chemistry – Metallurgy – 07 – K

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Details

C07K 5/117 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61P 7/02 (2006.01) C07K 5/02 (2006.01) C07K 5/023 (2006.01) C07K 5/087 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2355818

The invention is directed to substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators, their use in wound healing and preventing platelet aggregation. Pharmaceutical compositions comprising the substituted heterocyclic acyl-tripeptides of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

L'invention concerne des tripeptides acylés hétérocycliques substitués, utiles en tant que modulateurs du récepteur de la thrombine, leur utilisation dans la cicatrisation et dans la prévention de l'agrégation plaquettaire. Des compositions pharmaceutiques comprenant les tripeptides acylés hétérocycliques substitués de l'invention et des méthodes de traitement d'états induits par le récepteur de la thrombine participe sont également décrites.

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