Substituted heterocyclic compounds and methods of use

Details Substituted heterocyclic compounds and methods of use Substituted heterocyclic compounds and methods of use

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/506 (2006.01) A61K 31/513 (2006.01)

Patent

CA 2553923

The present invention relates to pyrimidinones and pyridones and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic .szlig. cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

L'invention concerne des pyrimidinones et des pyridones, ainsi que leurs dérivés et leurs sels pharmaceutiquement acceptables, et une méthode de traitement de l'inflammation, la polyarthrite rhumatoïde, la maladie de Paget, l'ostéoporose, les myélomes multiples, l'uvéite, la leucémie myéloïde aiguë ou chronique, la destruction des cellules .beta. pancréatiques, l'ostéoarthrite, la spondylarthrite ankylosante, l'arthrite goutteuse, la maladie intestinale inflammatoire, le syndrome respiratoire aigu sévère (SRAS), le psoriasis, la maladie de Crohn, la rhinite allergique, la colite ulcéreuse, l'anaphylaxie, la dermite de contact, l'asthme, la dégénération musculaire, la cachexie, le syndrome de Reiter, le diabète de type I, le diabète de type II, les maladies accompagnées de résorption osseuse, les réactions à des greffes, la maladie d'Alzheimer, les accidents cérébrovasculaires, l'infarctus du myocarde, les lésions ischémiques dues à la reperfusion, l'athérosclérose, les traumas cérébraux, la sclérose en plaques, l'accès pernicieux à forme cérébrale de paludisme, la sepsis, le choc septique, le syndrome du choc toxique, la fièvre, les myalgies dues au VIH-1, VIH-2, VIH-3, au cytomégalovirus (CMV), aux virus de la grippe, aux adénovirus, aux virus de l'herpès, l'herpès zoster chez des mammifères, ce traitement comprenant l'administration d'une quantité efficace d'un des composés décrits.

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