Substituted heterocyclic derivatives useful as antidiabetic...

Details Substituted heterocyclic derivatives useful as antidiabetic... Substituted heterocyclic derivatives useful as antidiabetic...

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/4164 (2006.01) A61K 31/4192 (2006.01) A61K 31/42 (2006.01) A61K 31/4245 (2006.01) A61K 31/454 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 233/54 (2006.01) C07D 249/06 (2006.01) C07D 263/32 (2006.01) C07D 271/06 (2006.01) C07D 401/02 (2006.01) C07D 413/02 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2490972

Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure (I) wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH~2)x where x is 1 to 5, or A is (CH~2)x1 where x1~ is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is -(CH~2)x2~-O-(CH~2)x3~- where x2~ is 0 to 5 and x3~ is 0 to 5, provided that at least one of x2~ and x3~ is other than 0; B is a bond or is (CH~2)x4~ where x4~ is 1 to 5; X is CH or N; X~2 is C, N, O or S; X~3 is C, N, O or S; X~4 is C, N, O or S; X~5 is C, N, O or S; X~6 is C, N, O or S; provided that at least one of X~2, X~3, X~4 X~5 and X~6 is N; and at least one of X~2, X~3, X~4, X~5 and X~6 is C, and specifically excluding the structure (II) where X~2 = N, X~3 = C, X~4 = O or S, Z = o or a bond; R1~ is H or alkyl; R2~ is H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; R2a~, R2b~ and R2c~ may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; and R3~ and Y are as defined herein, which compounds are useful in treating diabetes and obesity.

L'invention porte sur des compos~s qui sont utiles comme agents antidiab~tiques et agents anti-ob~sit~ et qui ont la structure (I) dans laquelle m vaut 0, 1 ou 2; n vaut 0, 1 ou 2; Q repr~sente C ou N; A repr~sente (CH´2?)x, x valant de 1 ~ 5, ou A repr~sente (CH´2?)x?1´, x?1´ valant de 1 ~ 5 avec une liaison alc~nyle ou une liaison alkynyle imbriqu~e ~ n'importe quel endroit de la cha¹ne, ou A repr~sente -(CH´2?)x?2´-O-(CH´2?)x?3´-, x?2´ valant de 0 ~ 5 et x?3´ de 0 ~ 5, ~ condition qu'au moins un de x?2´ et de x?3´ soit diff~rent de 0; B repr~sente une liaison ou repr~sente (CH´2?)x?4´, x?4´ valant de 1 ~ 5; X repr~sente CH ou N; X´2? repr~sente C, N, O ou S; X´3? repr~sente C, N, O ou S; X´4? repr~sente C, N, O ou S; X´5? repr~sente C, N, O ou S; X´6? repr~sente C, N, O ou S; ~ condition qu'au moins un de X´2?, X´3?, X´4? X´5? et X´6? repr~sente N; et qu'au moins un de X´2?, X´3?, X´4?, X´5? et X´6? repr~sente C, et sp~cifiquement excluant la structure (II) dans laquelle X´2? = N, X´3? = C, X´4? = O ou S, Z = o ou une liaison; R?1´ repr~sente H ou alkyle; R?2´ repr~sente H, alkyle, alcoxy, halog­ne, amino ou amino substitu~ ou cyano; R?2a´, R?2b´ et R?2c´ peuvent Útre identiques ou diff~rents et sont s~lectionn~s parmi H, alkyle, alcoxy, halog­ne, amino ou amino substitu~ ou cyano; et R?3´ et Y son tels que d~finis dans le descriptif. Ces compos~s sont utiles dans le traitement du diab­te et de l'ob~sit~.

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