Substituted heterocyclic diarylamine analogues

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/12 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) A61P 3/04 (2006.01) A61P 11/06 (2006.01) A61P 11/14 (2006.01) A61P 13/02 (2006.01) A61P 17/02 (2006.01) A61P 19/00 (2006.01) C07D 251/52 (2006.01) C07D 251/54 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2531401

Substituted heterocyclic diarylamine analogues of Formula I are provided: wherein X, Y and Z are independently N or optionally substituted C, and other variables are as described in the specification. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

L'invention concerne des analogues de diarylamine substitués hétérocycliques de la formule (I) dans laquelle X, Y et Z représentent indépendamment N ou C facultativement substitué, et d'autres variables sont décrites dans la description. Ces composés sont des ligands pouvant être utilisés pour moduler l'activité de récepteur spécifique in vivo ou in vitro, ils sont particulièrement utiles dans le traitement d'états associés à l'activation de récepteurs pathologiques chez des sujets humains, des animaux familiers domestiqués et des animaux d'élevage. L'invention présente également des compositions pharmaceutiques et des procédés d'utilisation de ceux-ci pour traiter de tels états, et également des procédés d'utilisation de ces ligands pour des études de localisation de récepteurs.

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