Substituted hexahydrobenzo[a]phenanthridines

Details Substituted hexahydrobenzo[a]phenanthridines Substituted hexahydrobenzo[a]phenanthridines

C - Chemistry, Metallurgy

07

D

C07D 221/18 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/695 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 491/056 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2135926

Trans-hexahydrobenzo[a]phenanthridine of formula (I) wherein R is hydrogen or C1-C4 alkyl; R1 is hydrogen or a phenoxy protecting group, X is fluoro, chloro, bromo, iodo or a group of the formula - OR5, and R2, R3, and R4 are independently selected from the group consisting of hydrogen, C1-C4 alkyl, phenyl, fluoro, chloro, bromo, iodo, or a group -OR1 provided that at least one of R2, R3, and R4 are other than hydrogen, are novel ligands for dopamine receptors.

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