Substituted hihydroquinolines as glucocorticoid mimetics,...

C - Chemistry – Metallurgy – 07 – D

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C07D 215/12 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61P 3/10 (2006.01) A61P 29/00 (2006.01) C07D 215/14 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2496175

Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, X, Y, and n are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

L'invention concerne des composés de formule (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, X, Y et n sont tels que définis dans le descriptif, ou un tautomère, un promédicament, un solvate ou un sel de celui-ci ; des compositions pharmaceutiques contenant ces composés, ainsi que des procédés permettant de moduler la fonction du récepteur de glucocorticoïde et des procédés permettant de traiter des états ou conditions pathologiques liés à la fonction du récepteur de glucocorticoïde, ou se caractérisant par des manifestations inflammatoires, allergiques ou proliférantes chez un patient utilisant ces composés.

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