Substituted hydrazones as inhibitors of cyclooxygenase-2

Details Substituted hydrazones as inhibitors of cyclooxygenase-2 Substituted hydrazones as inhibitors of cyclooxygenase-2

C - Chemistry, Metallurgy

07

C

C07C 311/39 (2006.01) A61K 31/18 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/63 (2006.01) C07C 311/49 (2006.01) C07D 209/14 (2006.01) G02B 6/12 (2006.01) G02B 6/124 (2006.01) G02B 6/125 (2006.01) G02B 6/28 (2006.01) G02B 6/34 (2006.01) G02B 6/35 (2006.01) H04Q 11/00 (2006.01)

Patent

CA 2469709

Compounds useful as inhibitors of cyclooxygenase-2 activity have the formulae I or Ia as defined herein. In addition, Figure 2 compares the growth inhibitory activity fo the Example 4 compound 4-bromobenzaldehyde-4- sulfamylphenylhydrazone and celecoxib against the human colo-rectal tumor cell line HT29.

L'invention concerne des composés utiles comme inhibiteurs de l'activité de la cyclooxygénase-2. Ces composés sont représentés par les formules (I) et (Ia), dans lesquelles Q<1>, Q<2>, n, m, X, Y et R sont tels que définis dans la description.

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